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Sequenced DNA reads with methylated and unmethylated CpGs go into cell-type deconvolution, which predicts the cell-type mixture.
Paper explainer · 15 September 2026

Classifying a tissue sample one DNA fragment at a time

Assigning a DNA fragment to its most likely cell of origin gets harder as the number of possible cell types grows. The solution turned out to be letting the model know when to remain unsure.

Rizdvanetskyi, Roos, LutsikNeurIPS 2026 · main track
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